2015 Annual Conference

March 5-7, 2015
Crowne Plaza St. Louis-Clayton
St. Louis, Missouri
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Session Highlights

Vascularizing Engineered (Cardiac and Tumor) Tissues In Vitro
Tissue engineering holds enormous potential to not only replace or restore function to a wide range of tissues, but also to capture and control three-dimensional physiology in vitro (e.g., microphysiological systems). The latter has important applications in the fields of drug development, toxicity screening, modeling tumor metastasis, and repairing damaged cardiac (heart) muscle. In order to replicate the complex 3-D arrangement of cells and extracellular matrix (ECM), new human microphysiological systems must be developed, and must include a vascular supply. The vasculature not only provides the necessary convective transport of nutrients and waste in 3-D culture, it also couples and integrates the response of multiple organ systems. The past decade has brought tremendous advances in our understanding of new blood vessel formation, providing a rich environment to vascularize engineered tissues. Over the past four years we have developed a novel microfluidic-based system of 3-D human microtissues (~ 1 mm3) perfused with a network of human microvessels. This seminar will describe our approach and early results, including applications in tumor biology and cardiac tissue.

About Steven George

Steven George joined Washington University in St. Louis as professor and chair of the Department of Biomedical Engineering in July 2014. Previously, he was a professor of biomedical engineering and of chemical engineering and materials science at the University of California, Irvine. In addition, he was the Edwards Lifesciences Professor and director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology and founding William J. Link Professor and chair of the Department of Biomedical Engineering at the University of California, Irvine from 2002-2009.

Professor George’s research interests include tissue engineering with particular interest in creating microphysiological systems, vascularizing engineered tissues and linking optical and mechanical properties of tissue. He has four active grants from the National Institutes of Health, including his role as principal investigator on a T32 training grant in cardiovascular technology and entrepreneurship. With a group of collaborators, he received one of only 12 grants from the NIH to create 3-D chips with living cells and tissues that accurately model the structure and function of human organs. His project seeks to create microtissue mimics of the heart, cancer and microcirculation. In addition, he is the principal investigator on a grant funded by the National Cancer Institute through the “Provocative Questions” program. This project seeks to develop new tissue-engineered inspired models of cancer cell metastasis.

Professor George has received numerous prestigious awards, including the National Science Foundation (NSF) CAREER Award; the Presidential Early Career Award for Scientists and Engineers (PECASE) from the NSF; the First Independent Research Support and Transition (FIRST) Award from the National Institutes of Health; Biomedical Engineering Professor of the Year of 2010 and many teaching awards. He is a member of the American Heart Association, the American Institute of Medical and Biological Engineering, the American Association for Cancer Research and the Biomedical Engineering Society. He has had more than 100 papers published in peer-reviewed journals and has written chapters for two books.

IBE 2015 Annual Meeting: General Session Speakers

Arthur T. Johnson

Arthur T. Johnson attended Cornell University for his undergraduate and graduate degrees. His PhD was awarded in 1969, and he immediately began serving as an officer in the US Army, eventually serving in Viet Nam at the rank of captain. He was awarded the Army Commendation Medal and Bronze Star Medal. He joined the faculty of the University of Maryland in 1975, and was Professor from 1986 until 2009, when he became Professor Emeritus. He was cochairman of the committee to found the American Institute for Medical and Biological Engineering (AIMBE) from 1988 to 1992, and served as the Executive Director of AIMBE in 2004. He has been President of the Alliance for Engineering in Medicine and Biology (1984-1988), Institute for Biological Engineering (1998), and International Society for Respiratory Protection (2004-2006). He was the Secretary of the Biomedical Engineering Society from 2004 to 2009. He has been on the Board of Directors of the American Society for Agricultural and Biological Engineers (1995-1997). He is a Founding Fellow of the American Institute for Medical and Biological Engineering (1992), Life Fellow of the American Society for Engineering Education (1996), Life Fellow of the American Society for Agricultural and Biological Engineers (2002), Fellow of the American Industrial Hygiene Association (2005), Fellow of the Biomedical Engineering Society (2005), Fellow of the Institute for Biological Engineering (2009), and the Life Fellow of the Institute for Electrical and Electronics Engineers (2010).

He is a member of the honor societies: Phi Kappa Phi, Sigma Xi, Tau Beta Pi, and Alpha Epsilon. He has written three books: Biomechanics and Exercise Physiology: Quantitative Modeling, Biological Process Engineering, and Biology for Engineers. His research interests are human performance wearing respiratory protective masks, respiratory mechanics and measurement, and transport processes. He has taught many course topics, including electronic design, transport process design, and engineering in biology. He is currently working to continue development of the Airflow Perturbation Device as a noninvasive measurement of respiratory resistance. He is also operating a 49 acre farm producing organically-raised fruit for sale at the local farmers’ market.

Ben Stuart

Ben Stuart is a Professor of Civil Engineering at Ohio University where he also serves as Executive Director of the Institute for Sustainable Energy and the Environment and as Director of the Biofuels Research Lab. Dr. Stuart has been a PI/co-PI/co-I or Principal Scientist on $21M worth of research projects externally funded by federal, state and industrial partners. His current research interests include biofuels production from waste and renewable (specifically algal biomass) feedstocks, CO2 capture using a novel membrane photobioreactor, and biomass gasification. His research in algal biofuels has led to three patents, as well as his participation as CTO in ECO2Capture, a start-up company focusing on developing and integrating enabling technologies in the algae cultivation and air pollution control markets. He is the author of over 35 refereed publications including three books and contributions to two additional books, has presented over 68 papers on his work, and has extensive consulting experience.

Dr. Stuart has served IBE as Secretary of the Executive Council for 2013-2014, is currently serving as President-Elect for 2015 and is eagerly anticipating serving as President in 2016. He has served as an IBE delegate to the KSBB Annual Conference in South Korea for the past two years, represented IBE at the USA Science and Engineering Festival in Washington D.C., and has served along with ASABE and NCEES as a PAKS Task Force Review member working on updates to the Agricultural and Biological Engineering PE Exam. Dr. Stuart received his Ph.D. from the Department of Chemical and Biochemical Engineering at Rutgers, the State University of New Jersey and he is a registered professional environmental engineer in the State of Ohio.

Brahm P. Verma

Brahm Verma is professor emeritus and associate director emeritus of the Faculty of Engineering which was officially organized as College of Engineering at the University of Georgia on July 1, 2012. Since the mid-1980’s he has championed for the emerging discipline of biological engineering and served as the founding president (1995-97) of the Institute of Biological Engineering (IBE) – A Society for Advancing Biology-Inspired Engineering. He has also created other organizations including the very successful Faculty of Engineering at the University of Georgia. The Faculty of Engineering conceptualized as a new kind of school/college of engineering with open borders and a self-organizing governance system influenced by living systems. The new College of Engineering - “A College without Borders” - has adopted the organizing principles of the Faculty of Engineering. Dr. Verma received BS (1959), MS (1965) and PhD (1968) degrees in agricultural engineering. Since 1965 he has over 350 publications and presentations at professional meetings and 2 patents. He has published on similitude in engineering; mechanization/automation of greenhouse and nursery; modeling using artificial intelligence techniques; and information systems and decision methodology.

He has received numerous awards, for example, ASAE best research paper awards, IBE Lifetime Visionary Award, ASAE/ASABE Fellow and IBE Fellow. The IBE Visionary Award is named after his wife and him (Brahm and Sudha Verma Visionary Award) to recognize visionary leaders in Biological Engineering. In retirement, Dr. Verma remains engaged in graduate education and the advancement of comprehensive engineering at UGA. He is a member of the UGA Teaching Academy and UGA Emeriti Scholars - a group of distinguished retired faculty members who continue to contribute towards building academic stature of the University of Georgia.

Jeong-Yeol Yoon

Jeong-Yeol Yoon received his B.S./M.S./Ph.D. degrees in Chemical Engineering at Yonsei University and his second Ph.D. in Biomedical Engineering at UCLA. He joined Department of Agricultural and Biosystems Engineering faculty at the University of Arizona in 2004 and holds joint appointments in School of Animal and Comparative Biomedical Sciences, Department of Biomedical Engineering and BIO5 Institute at the University of Arizona. Dr. Yoon has been active in Institute of Biological Engineering (IBE): he has received three presidential citations, worked as councilor-at-large, served as program chair/co-chair for its annual conferences. He currently serves as Editor-in-Chief for Journal of Biological Engineering (the official journal of IBE) and Associate Editor/Editorial Board Member for many other journals. Dr. Yoon has recently elected as President for IBE and will serve as President-Elect for 2014, President for 2015 and Immediate Past President for 2016.